Aging organisms tend to accumulate damaged cells, and when cells reach a certain point of damage, they go through an aging process to turn into senescent cells. The cells also release inflammatory factors that order the immune system to remove those damaged cells. A younger individual’s immune system is able to clear the damaged cells but in older people this process slows and becomes impaired, and they begin to accumulate, cause low level inflammation and release enzymes that can degrade the tissue.
As you know, fruits and vegetables offer a world of health-giving antioxidants, a broad range of phytochemicals that help keep us healthy by fighting off damaging chemicals called free radicals. Hundreds of antioxidants have been found to work specifically in the body, targeting cells, organs and systems to protect viability and structure.
According to a 2016 study, researchers noted that fisetin – a natural antioxidant found in various fruits (strawberries, apples, mangoes, persimmons, kiwis, and grapes), vegetables (tomatoes, onions, and cucumbers), nuts, and wine — has been shown to have many actions: anti-inflammatory, antioxidant, anti-tumorigenic, anti-angiogenic, neuroprotective, and cardioprotective effects in in vitro and in vivo studies. 1
New research published earlier this year in Nature Medicine involving University of Minnesota Medical School faculty and Mayo Clinic researchers showed it was possible to reduce the burden of damaged cells (called senescent cells), and extend lifespan and improve health, even when treatment was initiated later in life. The researchers now have shown that treatment of aged mice with fisetin also has significant positive effects on health and lifespan.
The team found that fisetin reduces the level of senescent cells in the body. They found this by treating mice towards the end of life with this compound and see improvement in health and lifespan. “These results suggest that we can extend the period of health, termed healthspan, even towards the end of life,” said co-author Paul Robbins. “But there are still many questions to address, including the right dosage, for example.” 2
In an earlier study on fisetin, the researchers noted that “fisetin has been shown to inhibit or retard the growth of various destructive cells in culture and implanted tumors in vivo. Fisetin targets many components of intracellular signaling pathways including regulators of cell survival and apoptosis, tumor angiogenic and metastatic switches by modulating a distinct set of upstream kinases, transcription factors and their regulators. Current evidence supports the idea that fisetin is a promising agent” for immune support. 3
Another outstanding source of antioxidants if Fucosea, a whole food supplement containing multiple vitamins, minerals, enzymes and omega 3 EFAs from sea plants and herbs.
1 Pal, et al. “Fisetin and Its Role in Chronic Diseases.” Adv Exp Med Biol. 2016;928:213-244.
2 Yousefzadeh, et al.”Fisetin is a senotherapeutic that extends health and lifespan.” EBioMedicine, 2018; DOI: 10.1016/j.ebiom.2018.09.015
3 Rengaraian, Yaacob. “The flavonoid fisetin as an anticancer agent targeting the growth signaling pathways.” Eur J Pharmacol. 2016 Oct 15;789:8-16.
Another Reason to Lose Weight: Obesity Increases Cancer Risk
As the weather continues to turn colder and the holidays are near, we turn to comfort foods, typically laden with sugars and refined carbs, making us gain some weight. Many people, unfortunately, don’t stop the cycle and slowly continue to gain weight as years go by. This may lead to obesity.
Obesity is associated with increased risk of developing and dying from numerous common cancers (breast, ovarian, kidney, colon, pancreatic, gastric, esophageal, thyroid, and gallbladder). Obesity is also linked with prostate cancer progression.
A newly published article in the Journal of the Academy of Nutrition and Dietetics has explored the link between obesity and various cancers – the authors estimated that about one-third of cancer cases are linked to dietary and other modifiable risk factors, especially for obesity-related cancers such as breast, colorectal, ovarian, endometrial, kidney, gallbladder, esophageal, and pancreatic cancers.
The American Cancer Society estimates there will be more than 1.7 million new cancer cases diagnosed in 2018. Previous research has suggested that poor diet is linked to development or exacerbation of cancer and that obesity increases the risk of many types of cancer as well as type 2 diabetes, and cardiovascular disease, as well as contributing conditions hypertension and chronic inflammation. Obesity rates have continued to incline, as much as tripling over the past 50 years, despite new, healthier foods
According to a 2016 report by the International Agency for Research on Cancer, excess body fat increases the risk for 13 types of cancer. In their review, lead investigator Stephen D. Hursting, PhD, MPH, and colleagues illuminated several significant mechanisms underlying the obesity-cancer link and assessed the dietary interventions that are currently being implemented in preclinical and clinical trials.
“Obesity-associated metabolic perturbations are emerging as major drivers of obesity-related cancer, including alterations in growth factor signaling, inflammation, and angiogenesis,” explained Dr. Hursting. “Preclinical evidence suggests that dietary interventions, such as calorie restriction, intermittent fasting, low-fat diet and the ketogenic diet, have the potential to reverse some of these obesity-associated alterations; however, more clinical data are needed to confirm translation to human subjects.” 1
In 2016, figures released by Cancer Research UK showed that obese women were found to have around a 40 percent greater risk of developing a weight-related cancer in their lifetime than women of a healthy weight.
“Losing weight isn’t easy, but you don’t have to join a gym and run miles every day or give up your favorite food forever,” said Dr. Julie Sharp, head of health information at Cancer Research UK. “Just making small changes that you can maintain in the long term can have a real impact.” 2
If you or a loved one has a lot of weigh tot lose, the journey begins with one step. You can also start taking good-quality dietary supplements, especially whole foods-based supplements such as Fucosea. This supplement gives you necessary macronutrients good fats, protein and fiber, as well as a wide range of micronutrients such as trace minerals, vitamins, antioxidants and omega-e EFAs.
1 “The connection between diet, obesity, and cancer: Nutrition experts explore the evidence: Dietary and lifestyle changes guided by registered dietitian nutritionists and other professionals can help reduce the incidence and progression of obesity-related cancers and support the recovery of cancer survivors.” Elsevier. ScienceDaily, 27 March 2018.
2 Cancer Research UK. “Obese women 40 per cent more likely to get cancer.” March 16, 2015